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- W2374598947 abstract "In order to determine the characteristics of T cell immune responses induced by recombinant Mycobacterium bovis BCG(rBCG)expressing MalE protein of Escherichia coli (rBCG·MalE),the splenocytes from immunized mice were treated to deplete CD4 + or CD8 + T cells by an immunomagnetic selection,then these cells were used to measure the IFN_γ of IL_2 responses to MalE protein or its peptides in enzyme linked immunospot (ELISPOT)assay.The results clearly indicated that T cell immune responses induced by rBCG·MalE were CD4 + T cell_dependent.The results of analyzing T cell responses to MalE protein or PPD in different time points ofter rBCG·MalE immunization showed that initial Thl responses to rBCG or BCG were modulated during the course of infection to become a mixed Th1/Th2 responses.These results revealed new mechanisms in T cell immune responese against mycobacteria,and further showed that BCG is an effective live vector to express and deliver foreign antigens to host immune system." @default.
- W2374598947 created "2016-06-24" @default.
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- W2374598947 date "2001-01-01" @default.
- W2374598947 modified "2023-09-25" @default.
- W2374598947 title "Kinetics of rBCG_initiated T Cell Immune Responses Monitored by ELISPOT Assay" @default.
- W2374598947 hasPublicationYear "2001" @default.
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