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- W2374601210 abstract "Objective To study the influence of thalidomide(Thd) on the expression of inflammatory factors,and explore the mechanism of thalidomide inhibiting atherosclerogenesis.Methods After serum collected,TNF-α,IL-8 and IL-1 levels were analyzed by ELISA kits,and total cholesterol(TC),high density lipoprotein(HDL),and triglyceride(TG) were detected by kits too.After the whole aorta was free,Sudan IV staining was used to visualize the atherosclerotic plaque area.HE staining was used to define the character of atherosclerotic plaque. Results Inflammatory response was induced by high lipid diet,which was confirmed by high level TNF-α,IL-8 and IL-1 in high lipid diet group compared with normal diet group.The expression of inflammatory factors was inhibited by thalidomide obviously,which was confirmed by low level TNF-α,IL-8 and IL-1 in high lipid diet group compared with high lipid diet added with drug group.Compared with high cholesterol group,the content of TC,LDL,HDL,TG in Thd group had no statistical difference.Athesosclerotic lesions existed in high lipid diet group.The size and the degree of athesosclerotic lesions decreased in high lipid diet added with drug group compared with high lipid diet group.Conclusion Thalidomide can inhibit the expression of inflammatory factors,which may be the important mechanism of thalidomide inhibiting atherosclerogenesis." @default.
- W2374601210 created "2016-06-24" @default.
- W2374601210 creator A5087088607 @default.
- W2374601210 date "2010-01-01" @default.
- W2374601210 modified "2023-09-23" @default.
- W2374601210 title "Thalidomide Inhibits the Expression of Inflammation Factors Induced by High Lipid Diet" @default.
- W2374601210 hasPublicationYear "2010" @default.
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