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- W2374612773 abstract "Objective: To understand the function of activity of hypothalamo-pituitary-adrenocortical (HPA) axis during heroin dependence and the changes of ACTH and cortisol during heroin related cue-induced craving. Methods: The blood levels of ACTH and cortisol were compared between heroin dependent patients shortly after detoxification (n=19) and control group (n=21). Self-reported craving, blood pressure, heart rates, diameter of pupil, blood level of ACTH and cortisol were measured in heroin dependent patients before and after heroin related cue exposure. Results: The blood level of cortisol in heroin dependent patients shortly after detoxification was higher compared with that in controls (t=3.142, P=0.003), the blood level of ACTH in heroin dependence patients also showed a higher tendency compared with that in controls (t=1.663, P=0.104). Heroin related cue exposure induced self reported craving, increased the heart rates, blood pressure, and the diameter of pupil in heroin dependent patients, but did not produce significant changes in their blood levels of ACTH and cortisol (P0.05). Conclusion: The HPA axis is increased shortly after detoxification in heroin dependent patients. Heroin related cue exposure induces craving and produces physiological changes among heroin dependent patients. It is suggested that to decrease the sensitivity of drug use related cues may be of help to decrease craving and prevent relapse." @default.
- W2374612773 created "2016-06-24" @default.
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- W2374612773 date "2006-01-01" @default.
- W2374612773 modified "2023-09-23" @default.
- W2374612773 title "CHANGES OF THE ACTIVITY OF HYPOTHALAMO-PITUITARY-ADRENOCORTICAL AXIS DURING HEROIN DEPENDENCE AND CUE-INDUCED CRAVING" @default.
- W2374612773 hasPublicationYear "2006" @default.
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