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- W2374617943 abstract "Inhalation drug delivery is a new non-invasive delivery system which possesses several advantages,such as extending drug duration,enhancing therapeutic effect and elevating patient compliance.The preparation of the drug-loading matrix for the inhalation drug delivery is a study focus.In order to prepare more uniform and smaller drug-loading microparticles,an experimental apparatus for supercritical antisolvent(SAS) process was set up.The drug-loading microparticles of poly-l-lactide(PLLA) were prepared by SAS process with dichloromethane-acetone(1:1,V:V) as mixed solvent.The effects of process parameters including the pressure,the temperature,the solution concentration and the solution flow rate,on the particle size and particle size distributions were investigated experimentally.The results show that the PLLA microparticles prepared with acetone and dichloromethane as mixed solvent are much smaller and more uniform.The morphology of the most microparticles prepared is globular.Using SAS process,the PLLA microparticles with diameters of 0.8~4 μm can be obtained by adjusting process parameters,and the prepared micropaticles are suitable for inhalation delivery system." @default.
- W2374617943 created "2016-06-24" @default.
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- W2374617943 date "2011-01-01" @default.
- W2374617943 modified "2023-09-24" @default.
- W2374617943 title "Preparing Microparticles for Inhalation Drug Delivery by Supercritical Antisolvent Process" @default.
- W2374617943 hasPublicationYear "2011" @default.
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