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- W2374627517 abstract "OBJECTIVE:To explore the therapeutic effect of Chinese herbal compounds Zhiganle on fatty liver induced by high-cholesterol high fat diet in rats and the action mechanism.METHODS:Wistar rats were randomized into 6 groups:normal group,model group,Dongbao gantai group,ZGL groups(high,middle,and low doses).Except the normal group,the other 5 groups of rats were administered with high-cholesterol high fat diet for 12 weeks.On week 13,the ZGL groups were administered intragastrically with Zhiganle(1.5,3.0,4.5 g·kg-1) and rats in Dongbao gantai group with Dongbao gantai(0.3 g·kg-1) qd for 12 consecutive weeks.The hematological indexes were measured and the pathological change in rats was observed.RESULTS:In ZGL groups,serum levels of total cholesterol(T-CH) and triglyceride(TG) and the MDA level in liver were decreased significantly(P0.01 or P0.05),while the level of GSH(glutathione),MT(metallothionein),CYP450 in liver and TNF-2 in blood serum were increased remarkably(P0.01 and P0.05),and the pathological change improved significantly.CONCLUSION:The results showed that Zhiganle has remarkable anti-lipid peroxidation and its anti-fatty liver effect was achieved by promoting the elimination of lipid from liver thus reducing the accumulation of lipid in liver." @default.
- W2374627517 created "2016-06-24" @default.
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- W2374627517 date "2008-01-01" @default.
- W2374627517 modified "2023-09-23" @default.
- W2374627517 title "Antis-lipid Peroxidation of Zhiganle in Rats with Fatty Liver" @default.
- W2374627517 hasPublicationYear "2008" @default.
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