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- W2374643301 abstract "AIM:To explore the apoptosis-inducing effect of mimics of manganese superoxide dismutase (MnSODm) on human multidrug-resistant leukemia cell line K562/ADM in vitro and the possible molecular mechanisms. METHODS:The apoptosis of K562/ADM cells was assessed with FITC-Annexin V and propi-dium iodide (PI) double staining and morphological observation. Expressions of Bcl-2 and Bax proteins,mitochondrial inner membrane potential (Δψm),cytochrome c (Cyt c) release,and caspase-3 activity were analyzed by flow cytometry (FCM). RESULTS:After treatment with 10-50 mg/L MnSODm,the apoptosis rate of K562/ADM cells by Annexin V/PI staining was obviously increased to 85.1%-96.8%,and appearance of typical apoptotic morphological changes of K562/ADM cells was observed by optical and electron microscopes. FCM revealed that the expression of Bcl-2 protein was decreased by 32%-73% and that of Bax protein was increased 4-10 times obviously,accompanied with the disruption of mitochondria Δψm by 35%-52%,and the increased release of Cyt c by 28%-75% from mitochondria to cytoplasm. The activity of caspase-3 was significantly enhanced by 5.1-6.4 times. CONCLUSION:MnSODm down-regulates Bcl-2 protein and up-regulates Bax protein expression,and induces apoptosis of K562/ADM cells through the mitochondrial pathway." @default.
- W2374643301 created "2016-06-24" @default.
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- W2374643301 date "2008-01-01" @default.
- W2374643301 modified "2023-09-23" @default.
- W2374643301 title "Apoptosis of K562/ADM cells induced by MnSODm through mitochondrial pathway" @default.
- W2374643301 hasPublicationYear "2008" @default.
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