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- W2374647372 abstract "Objective:To investigate the changes of the brain tissue IL-1,IL-6 and IL-8 mRNA expression in rat models with hypoxic-ischemic brain damage,and to demonstrate whether cytokines were involved in the injury process after hypoxic-ischemic brain damage.Methods:Unsexed SD rats were randomly divided into shamming operation group and HIBD group.Rat models of acute brain hypoxic-ischemic were established.The expression of IL-1,IL-6 and IL-8 mRNA at days 1,3 and 7 respectively after injection was measured by rt-PCR method.Results:The expression of IL-1,IL-6 and IL-8 mRNA in hypoxic-ischemic brain hemisphere was significantly higher than that in shamming operation group as time went by after HIBD(P0.05).The expression of IL-1 and IL-8 mRNA was increased to the highest level at day 3,and then was lowed with times.The level of IL-6 mRNA was the peak,and then was down-regulation.Conclusion:IL1,IL-6 and IL-8 mRNA are mainly involved in the process of hypoxic-ischemic brain injury,and cytokines might be someway related to the pathogenesis of this syndrome." @default.
- W2374647372 created "2016-06-24" @default.
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- W2374647372 date "2008-01-01" @default.
- W2374647372 modified "2023-09-24" @default.
- W2374647372 title "Changes and significance of IL-1,IL-6 and IL-8mRNA in hypoxic-ischemic brain damage in rats" @default.
- W2374647372 hasPublicationYear "2008" @default.
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