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- W2374647567 abstract "Objective To construct α-synuclein over-expressed cell model and study cytotoxicity and mechanisms of α-synuclein overexpression,which might reveal possible pathogenesis of Parkinson's disease (PD) and provide novel targets for drug research and development (RD) of PD therapy.Methods The recombinant pEGFP-N1-α-synuclein vectors were transfected via LipofectamineTM 2000 to generate α-synuclein over-expressed cells that could be observed under a fluorescence microscope.Then,the transgenic cells were subjected to Western blot assay,MTT assay,PI staining and luciferase assay respectively.Results Over-expression of α-synuclein did not influence the differentiation of PC12 cells,however,could decrease cell viability significantly and aggravate the injury of serum starvation or neurotoxin MPP+.Furthermore,α-synuclein over-expression could aggravate MPP+ induced inhibition of transcription factor NF-κB mediated luciferase expression by inhibition of IκB-α phosphorylation.Conclusions Combinations of genetic factor and environmental factor in experimental models make the study of PD pathogenesis more scientific and rational.Moreover,the inhibition of NF-κB signaling pathway is regarded as a potential mechanism of PD pathogensis.Thus,a further study of proteins changes presented in the signal pathway should be necessary for novel targets discovery of PD therapy and the followed drug RD." @default.
- W2374647567 created "2016-06-24" @default.
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- W2374647567 date "2010-01-01" @default.
- W2374647567 modified "2023-09-25" @default.
- W2374647567 title "Cytotoxicity of α-synuclein over-expression and the effects on injury stimulus" @default.
- W2374647567 hasPublicationYear "2010" @default.
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