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- W2374659576 abstract "Objective: To explore the effects of 8-week aerobic treadmill training on learning and memory and ChAT and AchE mRNA expression in hippocampus of D-galactose(D-gal) AD rats.Materials methods:20 male SD rats were randomly divided into the control group(C,n=10),exercise group(T,n=10).Group C and T rats were injected D-gal(120 mg/kg·d) in the abdominal for 8 weeks to make aging animal models.Group T was given aerobic treadmill,five times a week for 8 weeks.All rats participated in the Morris Water Maze(MWM) test for 6 days during the 9th week.The expression level of ChAT and AchE mRNA in hippocampus of all rats are inspected by real-time fluorescence quantitative PCR.Results: 8-week aerobic treadmill exercise may enhance the abilities of learning and memory of T group of rats in MWM and significantly up-regulate the expression of ChAT mRNA(31.2%,P0.01) and down-regulate the expression of AchE mRNA(17.5%,P0.05) in hippocampus.Conclusion: 8-week aerobic treadmill training can alleviate the decrease of learning and memory of D-gal AD rats,which may be related with the higher expression of ChAT mRNA and lower expression of AchE mRNA that may regulate the content of Ach in hippocampus of rats." @default.
- W2374659576 created "2016-06-24" @default.
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- W2374659576 date "2013-01-01" @default.
- W2374659576 modified "2023-09-23" @default.
- W2374659576 title "Alleviation Function of Treadmill Exercise on the Decrease of Learning and Memory and Its Relationship with ChAT and AchE in Hippocampus of D-galactose AD Rats" @default.
- W2374659576 hasPublicationYear "2013" @default.
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