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- W2374688514 abstract "Objective To explore the effects of Tripterygium Hypoglaucum (Levl) Hutch (THH) alkaloids on the apoptosis of Jurkat T lymphoma cells via the mitochondrial pathway. Methods After Jurkat cells were induced by THH alkaloids at different doses and at different time points, Bcl 2 expression was detected by Western blotting. Apo2.7 molecules on mitochondrial membrane and mitochondrial membrane potential (ΔΨm) were measured by JC 1 staining, immunocytochemistry and flow cytometry. Results THH alkaloids could effectively reduce mitochondrial membrane potential and Bcl 2 expression and increase Apo2.7 molecule expression in Jurkat cells. Conclusion THH alkaloids can induce the apoptosis of T lymphoma cells via the mitochondrial pathway. Bcl 2 takes part in the role of the starting of apoptotic function of mitochondria." @default.
- W2374688514 created "2016-06-24" @default.
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- W2374688514 date "2003-01-01" @default.
- W2374688514 modified "2023-09-25" @default.
- W2374688514 title "Tripterygium Hypoglaucum (Levl) Hutch alkaloids induce the apoptosis of T lymphoma cells via the mitochondrial pathway" @default.
- W2374688514 hasPublicationYear "2003" @default.
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