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- W2374706997 abstract "Objective To investigate the prevalence and types of the mutation of mitochondrial 12S rRNA in cochlear implant recipients. Methods A total of 100 Chinese patients with non-syndromic hearing impairment (96 with pre-lingual hearing loss and 4 with post-lingual hearing loss), who had received cochlear implantation, were enrolled in this study. Genomic DNA was extracted from the peripheral blood of the patients. After PCR amplification and purification, the mitochondrial 12S rRNA fragment was sequenced. Results Among the 100 cases, 1555AG mutation was found in 2 cases, and delT961Cn mutation was detected in 1. The overall rate of detection of pathogenic gene was 3%.Conclusion Mutation of mitochondrial 12S rRNA is not the main cause of hearing impairment in cochlear implant recipients." @default.
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- W2374706997 date "2008-01-01" @default.
- W2374706997 modified "2023-09-27" @default.
- W2374706997 title "Mutation of the mitochondrial 12S rRNA gene in cochlear implant recipients" @default.
- W2374706997 hasPublicationYear "2008" @default.
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