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- W2374733360 abstract "Objective To establish a rabbit model of thrombotic plaque erosion.Methods Twenty-four male New Zealand rabbits underwent post-balloon-injury with high-cholesterol feeding for 3 months.After 3 months,the aortas of all rabbits were induced with 5×10~(-5)mol/L staurosporin(experimental group)or saline(control group).After 3 days,all aortas underwent angiography and thrombotic score was made,and the segments triggered with drugs were cut in serious sections.The sections were stained with hematoxylin and eosin,Oil Red O,CD31 antibody,α-actin antibody and terminal deoxynucleotidyl transferase-mediated dupt nick end Lableling(TUNEL)kits.Endothelial integrity score and apeptosis score were carried out according to CD31 antibody and TUNEL staining respectively.Results Angiography showed that obvious thrombosis(thrombotic score 3-4)occurred in 7 rabbits in the experimental group(7/12),and didn't in the controls (0/9).Serious sections of the processed aortas revealed that there were more histological thrombosis in the experimental group than in the control group(10/12 vs.1/9,P＜0.01).The experimental group showed many histoligieal changes including small or large area of endothelial exfoliation on the surface of plaques with CD31 staining,a lot of smooth muscle cells in fibrous caps withα-actin staining,deep lipid of plaques without communication with thrombi in lumens with Oil Red O staining,and no rupture of fibrous caps was observed in this group.There were lower endothelial integrity scores and higher apoptosis scores in the experimental group is comparsion with controls.Conclusion The model of thrombotic plaque erosion could be established by inducing endothelial denudation of stable atherosclerotic plaques with staurosporin,and endothelial apoptosis might play a vital role in thrombotic plaque erosion." @default.
- W2374733360 created "2016-06-24" @default.
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- W2374733360 date "2006-01-01" @default.
- W2374733360 modified "2023-09-23" @default.
- W2374733360 title "Experimental research about establishing a model of atherosclerotic plaque erosion" @default.
- W2374733360 hasPublicationYear "2006" @default.
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