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- W2374738716 abstract "Objective: To explore the relationship between serum leptin level and insulin resistance(IR) in patients with simple obesity.Methods: Height,body weights,waist and hip circumference were determined in 70 cases of simple obesity and 42 healthy controls. Simultaneously, alterations of serum leptin level, fasting serum true insulin(TI) concentration and fasting plasma glucose(FPG) were also detected by radioimmune assay respectively, double antibodies sandwich technigue and glucose oxidase method,the Insulin senstivity index (ISI) was calculated [ISI=I/(FPG×FINS)]. The correlation among above detected markers was analyzed using multiple regression analysis and partial correlation analysis respectively.Results: The serum leptin and TI levels were obviously higher in patients with simple obesity than those of sex-matched healthy controls (P0.01), but ISI was remarkable lower than that in healthy controls (P0.01).In order of arrange for the best important factors of influencing serum leptin level as follows:sexbody massindex(BMI)TIISI(R2=0.527,P0.01). After deleted the influence of sex difference and BMI size,the serum leptin level was positively correlated with TI level(r=0.597,P0.01),but it was negatively correlated with ISI obviously (r=-0.468,P0.01).Conclusions: There is leptin and insulin resistance in the patients with simple obesity, and both have close correlation." @default.
- W2374738716 created "2016-06-24" @default.
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- W2374738716 date "2004-01-01" @default.
- W2374738716 modified "2023-09-25" @default.
- W2374738716 title "Relationship between alteration of serum leptin level and insulin resistance in simple obesity patients" @default.
- W2374738716 hasPublicationYear "2004" @default.
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