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- W2374741008 abstract "Objective To investigate the effect of a Chinese herbs mixture(Monkshood,ginger and licorice)on blood pressure(BP)and its possible mechanism in renovascular hypertensive rats.Methods 2K1C hypertensive rats received placebo(n=8)or Sinitung(n=8)by gavage for 2 weeks.BP was measured by tail-cuff.Plasma angiotensin Ⅱ(Ang Ⅱ)and calcium gene related peptide(CGRP)were examined by histochemical assay.Results Sinitang treatment significantly decreased BP(116.2±8.3 mm Hg vs placebo:131.6±14.2 mm Hg,P0.05).Although no differences in plasma Ang Ⅱ was found compared with placebo,plasma CGRP was markedly higher(75.2±12.2 vs placebo:54.8±18.1,P0.05).The number of TUNEL positive cells in renal tubule was decreased in treatment group compared with placebo(12.6±3.5 vs placebo:29.4±3.5 cell number/10 visual fields,P0.05),which was associated with reduced expression in Ang Ⅱ and increases in CGRP in glomeruli.Conclusion Sinitang decreased BP and protected the target organs in association with decreases in Ang Ⅱ and increases in CGRP in renal tissue in renovascular hypertensive rats." @default.
- W2374741008 created "2016-06-24" @default.
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- W2374741008 date "2007-01-01" @default.
- W2374741008 modified "2023-09-24" @default.
- W2374741008 title "Effect of Chinese Herb Sinitang (Monkshood,ginger and licorice) on Blood Pressure in Renovascular Hypertensive Rats" @default.
- W2374741008 hasPublicationYear "2007" @default.
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