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- W2374772826 abstract "Objective To study the effect of whole Bifidobacterial peptidoglycan(WPG) as an immune adjuvant on the cellullar immunologic response induced by the Hantaan nucleocapsid protein(HTNV-NP).Methods WPG was extracted and mixed with HTNV-NP,then vaccinated to BALB/c mice.Activities of NK cells and CTL and lymphocyte proliferation test were measured.Levels of IL-2 and IFN-γ were also determined by ELISA.The safety of WPG was studied,too.Results In HTNV-NP group,activities of NK cells and CTL were(5.16±1.34)%and(28.46±4.16)% respectively.The stimulating index of lymphocyte proliferation was 1.7.Levels of IL-2 and IFN-γ were(89.65±7.63) pg/ml and(245.68±56.74) pg/ml respectively.In HTNV-NP+WPG group,activities of NK cells and CTL were(9.85±0.87)% and(43.29±5.54)% respectively.The stimulating index of lymphocyte proliferation was 3.1.Levels of IL-2 and IFN-γ were(204.48±36.17) pg/ml and(473.29±74.94) pg/ml respectively.The difference between HTNV-NP group and HTNV-NP+WPG group was significant(P0.01).Mice in HTNV-NP+WPG group had not any side effect. Conclusion The results indicate that WPG is a good immune adjuvant which can enhance the immune response induced by HTNV-NP significantly." @default.
- W2374772826 created "2016-06-24" @default.
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- W2374772826 date "2007-01-01" @default.
- W2374772826 modified "2023-09-25" @default.
- W2374772826 title "The effect of whole Bifidobacterial peptidoglycan on the cellullar immunologic response induced by Hantaan virus neucleoprotein" @default.
- W2374772826 hasPublicationYear "2007" @default.
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