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- W2374784124 abstract "Objective To observe the expression of IL-10 and MMP-9 in human non-small cell lung canncer(NSCLC)and investigate the correlation of the expression with the invasion,metastasis and prognosis of NSCLC. Methods The expression levels of IL-10 and MMP-9 were detected in 60 NSCLC specimens and 20 cases of benign pulmonary lesions by using immunohistochemistry. We compared the relationship of clinical features and prognosis with IL-10 and MMP-9 by using single-factor(Log-rank) survival analysis. Results The positive rate of IL-10 and MMP-9 expression was significantly increased in NSCLC than that in benign pulmonary lesions(P 0.05). The IL-10 expression was negatively correlated with the MMP-9 expression,the survival time of the IL-10 low expression group was less than that of its high-expression group,and the survival time of the MMP-9 low expression group was longer than that of its high-expression group (P0.05). The high expression of IL-10 and the low expression of MMP-9 might have an impact on the prognosis of NSCLC. Conclusion The expression of IL-10 and MMP-9 has an impact on NSCLC,and the expression of the two is relevant. IL-10 may inhibit metastasis of tumor cells by inhibiting the expression of MMP-9. Therefore,monitoring the expression of IL-10 and MMP-9 may play an important role in tne assessment of the prognosis of NSCLC patients." @default.
- W2374784124 created "2016-06-24" @default.
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- W2374784124 date "2009-01-01" @default.
- W2374784124 modified "2023-09-24" @default.
- W2374784124 title "Expression of IL-10 and MMP-9 in Non-small Cell Lung Cancer and Its Correlation with Prognosis" @default.
- W2374784124 hasPublicationYear "2009" @default.
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