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- W2374801809 abstract "Objective:To construct KDR gene recombinant T7 phage vaccine and investigate its anti-tumor effect on mice with Lewis lung cancer.Methods:The gene encoding the domainⅡof the extracellular region of KDR was cloned into the T7 phage genome to construct phage vaccine.Then the vaccine was applied to immune mice.After the 4th immunization,Lewis lung cancer cells were inoculated.The weight of tumor was determined after 14 d to investigate the anti-tumor effect.The serum level of the specific antibody against human KDR was determined by ELISA.Results:The recombinant T7 phage was successful- ly constructed.The tumor growth in the experimental group was inhibited most obviously and the tumor weight in this group was significantly lower than that in both the normal saline group and phage control group (P＜0.05).And its tumor inhibition rate was 57.0%,which was significantly higher than the phage control group (16.0%).Specific antibody against human KDR was still positive by ELISA when the mouse serum was diluted to 1/500.Conclusion:The KDR gene recombinant phage vaccine had obvious anti-tumor effect on mice with Lewis lung cancer.Homo sapiens KDR phage vaccine could break the immune toler- ance of mice to self-antigen through cross-reaction and induce specific anti-tumor immunity." @default.
- W2374801809 created "2016-06-24" @default.
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- W2374801809 date "2006-01-01" @default.
- W2374801809 modified "2023-09-26" @default.
- W2374801809 title "Construction of KDR gene recombinant T7 phage vaccine and its inhibitory effect on Lewis lung cancer in mice" @default.
- W2374801809 hasPublicationYear "2006" @default.
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