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- W2374804898 abstract "Objective To investigate the effect of Imidapril on left ventricular mass index(LVMI), heart rate corrected QT interval dispersion(QTcd)and ventricular arrhythmia(VA)in patients with left ventricular hypertrophy(LVH)caused by essential hypertension.Methods 170 hypertenstion patients with LVH were divided randomly into two groups. 86 patients in Amolodipine group were treated routinely. 84 patients in Imidapril group were treated with routine drugs plus Imidapril. LVMI,QTcd of 12 - lead surface ECC and VA malignant degree recorded by Holter were analyzed before therapy and 1 year after therapy.Results In the Amolodipine group, the change of LVMI before and after the therapy was not significant(152±17 g/m2vs 151±17 g/m2, P 0.05), the change of QTcd before and after the therapy was not significant(75±12 ms vs 73±12ms, P 0.05). In the Imidapril group, the change of LVMI before and after the therapy was not significant ( 153 ±18 g/m2 vs 140 ?16 g/m2 , P 0.01) ,the change of QTcd was significant More and after the therapy(74±12 ms vs 65±9 ms, P 0.05). Before the therapy, QTcd and the malignant degree of VA between the two groups were not significantly different, but both of the indexes between the two groups were significantly different after the therapy. There were significant difference between LVMI and QTcd in patients with LVH caused by hypertension ( r =0.33,P 0.01) .Conclusion Treatment with Imidapril can significantly reduce the QTcd and the malignant degree of VA in patients with LVH caused by hypertension." @default.
- W2374804898 created "2016-06-24" @default.
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- W2374804898 date "2004-01-01" @default.
- W2374804898 modified "2023-09-23" @default.
- W2374804898 title "Effect of Imidapril on QT interval dispersion and ventricular arrhythmia in patients with left ventricular hypertrophy caused by hypertension" @default.
- W2374804898 hasPublicationYear "2004" @default.
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