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- W2374810568 abstract "OBJECTIVE To study the impacts of transfersomes in vivo administration of sinomenine.METHODS The sinomenine transfersomes were prepared by the mothod of membrane-dispersion.The impacts of transfersomes on absorption,distribution and central and peripheral analgesic effect of sinomenine were researched by determining concentrations of sinomenine in blood and brain tissue under intravenous injection and transdermal delivery.RESULTS Permeation dose of transfersomes via transdermal pathway was remarkably improved which significantly increases not only the concentrations of it in blood but also the mount of it in brain tissue,and analgesic effect was improved remarkably.The mount of transfersomes in brain tissue which significantly increases sedation-analgesic effect was increased but to some extent,the concentration of transfersomes in blood the was reduced which lowers peripheral anti-inflammatory and analgesic effect.CONCLUSION Transfersomes was able to notablely improve the absorption,distribution of sinomenine and had an effect on its pharmacodynamics." @default.
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- W2374810568 date "2011-01-01" @default.
- W2374810568 modified "2023-09-23" @default.
- W2374810568 title "Studies on Transdermal Pharmacokinetic and Pharmacodynamics of Sinomenine Transfersomes" @default.
- W2374810568 hasPublicationYear "2011" @default.
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