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- W2374811178 abstract "Objective To analyze the acute toxicity by intragastric gavage administrated with Slug capsule in mice,so as to observe its safety and to provide information for clinical studies.Methods The mice were treated with Slug capsule by intragastric gavage once.Their general condition,including weight,food intake,drinking,stool,urine,reaction for environment,was observed for 14 d.The time of toxic reaction emerge,phenotype of the symptom,duration of the toxic reaction,mortality rate,the half lethal dose(LD50) and the maximum tolerated dose(MTD) were measured.Results The experimental mice were still alive without any toxic reaction by intragastric gavage for 14 d with the dose 8 800 mg·kg-1·d-1,which was equivalent to 880 times of clinical daily dosage of 70 kg adult.The LD50 and MTD of Slug capsule in this experiments had not been collected.Conclusion Slug capsule has showed low toxicity,it is safe and reliable to be taken at the prescribed does." @default.
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- W2374811178 date "2012-01-01" @default.
- W2374811178 modified "2023-09-23" @default.
- W2374811178 title "Experimental Study on Acute Toxicity of Slug capsule" @default.
- W2374811178 hasPublicationYear "2012" @default.
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