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- W2374815242 abstract "Objective:To investigate the effects of tetrandrine(Tet) on proliferaton and apoptosis of nasopharyngeal carcinoma cell line CNE.Methods:CNE cells were divided into groups and treated by Tet at different concentrations.Inhibitory effects of tetrandrine were determined by MTT assay.The morphologic changes of CNE cells were observed by transmission electron microscope.DNA fragmentations were determined by gel electrophoresis assay.Cell apoptosis was investigated by flow cytometer.The expressions of apoptosis-related genes were detected by retrotranscriptase polymerase chain reaction(RT-PCR).Results:Tetrandrine possessed inhibitory effect on CNE cell proliferation in a concentration-dependent manner(P0.05).When treated with Tet for 72 h,cell shrinkage,nuclear fragmentation and apoptotic body formation were observed under transmission electron microscope.With concentration of Tet raised,ladder-shaped straps in DNA gel electrophoresis and apoptosis manifested gradually.Compared with those of control group,expression of Bcl-2 mRNA decreased gradually;but expression of Bax mRNA increased gradually(P0.05). Conclusion:Tetrandrine may inhibit growth of cancer cell,induce apoptosis.The anti-cancer mechanism of Tet may be involved in up-regulation of Bax gene expression and down-regulation of Bcl-2 gene expression." @default.
- W2374815242 created "2016-06-24" @default.
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- W2374815242 date "2007-01-01" @default.
- W2374815242 modified "2023-09-26" @default.
- W2374815242 title "Effects of tetrandrine on proliferation and apoptosis of nasopharyngeal carcinoma cell line CNE" @default.
- W2374815242 hasPublicationYear "2007" @default.
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