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- W2374817055 abstract "【Objective】To study the effects of lamivudine in treating chronic hepatitis B (CHB),and the condition of the tyrosine-methionine-aspartic acid-aspartic acid(YMDD) mutation in hepatitis B virus(HBV) polymerase gene after lamivudine therapy.【Methods】Fifty eight CHB cases were analyzed with HBV DNA,ALT and HBVM before and after lamivudine treatment,the HBV YMDD mutation was also studied after the treatment.【Results】After lamivudine treatment,HBeAg negative rate was 40.38%,eAg/ anti-e serum conversion rate was 28.85%,the HBV DNA negative rate was 74.14%,the ALT recovery rate was 77.59%.Along with the extension of the lamivudine treatment,65.12% cases rebounded.YMDD mutation was found in 23 cases,and was the main form in mutation types.The period of treatment was related with the mutation of YMDD,no relativity was found between ex-treatment HBV carry and YMDD mutation(P0.05).No difference was found in YMDD mutation rate between HBeAg positive cases and HBeAg negative cases(P0.05).(【Conclusion】)Lamivudine treatment is effective on CHB in short-term,but along with the period extension,the virus would be drug fast with lamivudine by mutation of YMDD.The mutation of YMDD might be responsible for the hepatitis relapse or aggravating liver injures.The drug fast of lamivudine in the virus is also caused possibly by mutation in other HBV gene sites." @default.
- W2374817055 created "2016-06-24" @default.
- W2374817055 creator A5031963795 @default.
- W2374817055 date "2006-01-01" @default.
- W2374817055 modified "2023-09-22" @default.
- W2374817055 title "Clinical Effect of Lamivudine in Treating Chronic Hepatitis B and YMDD Mutation" @default.
- W2374817055 hasPublicationYear "2006" @default.
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