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- W2374826117 abstract "This experiment was conducted to study the preparation of ivermectin nanoemulsion(5%) and its physicochemical properties,drug loading efficiency,stability and acute toxicity were evaluated.The physicochemical properties of ivermectin nanoemulsion was tested by the pseudoternary phase diagram method with the idex of viscosity,conductivity,refractive property,Z potentiometer and average diameter in normal temperature;The stability of ivermectin nanoemulsion was investigated with the idex of drug loading efficiency in different temperature,illumination and humidity;The acute toxicity was evaluated with the method of rat oral perfusion while the drug loading efficiency was detected by HPLC method.The results were as follows: 1)The ivermectin nanoemulsion was small spherical drops when observed by the electron microscopy and the average diameter was about 70 nm;2)The ivermectin nanoemulsion was stable in different temperature,illumination and humidity;3)The nanoemulsion(0.1%) was innoxious for mice when tested by the acute toxicity test.These results indicated that the preparation methods of ivermectin nanoemulsion(5%) was simple,and the preparation of ivermectin nanoemulsion was stable and with high safety quality." @default.
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- W2374826117 date "2011-01-01" @default.
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- W2374826117 title "Preparation and Property Evaluation of Ivermectin Nanoemulsion for Injection" @default.
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