Matches in SemOpenAlex for { <https://semopenalex.org/work/W2374840988> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2374840988 abstract "Objective: To investigate the expression of VEGF and its receptors Flt-1 and Flk-1 in surrounding tumor cells of LPPCN-positive group and VM-positive group in 70 melanoma cases,and study their roles in tumor novel vessel construction and their clinical significance.Methods: HE staining and CD31/PAS double staining were used to judge the LPPCN-positive group and VM-positive group in 70 cases of melanoma.Immunohistochemical method was used to detect the expression of VEGF and its receptors Flt-1 and Flk-1 in 1~3 layers,4~6 layers and 7~9 layers of melanoma cells surrounding LPPCN and VM in LPPCN-positive group and VM-positive group in 70 cases.Kaplan-Meier survive plot was used to compare VEGF-positive group and VEGF-negative group.Results: LPPCN-positive cases were 38 cases,VM-positive cases were 33 cases.The expression of VEGF and Flk-1 in 1~3 layers surrounding LPPCN was higher than those in 4~6 layers and 7~9 layers(P0.01).The expression of Flt-1 had no statistical significance(P0.05).The expression of VEGF,Flt-1 and Flk-1 surrounding VM also had no statistical significance(P0.05).Kaplan-Meier survive plot showed that the survival time of VEGF-positive surrounding LPPCN group was shorter than VEGF-negative group(P0.05).The positive rate of VM in VEGF-positive group was higher than that in VEGF-negative group(P0.05).Conclusion: The results show that VEGF and Flk-1 can play critical roles in the early stage of formation of VM in melanoma and the expression of VEGF and its receptor Flk-1 are associated with clinical prognosis of the patients with melanoma." @default.
- W2374840988 created "2016-06-24" @default.
- W2374840988 creator A5049567302 @default.
- W2374840988 date "2011-01-01" @default.
- W2374840988 modified "2023-09-23" @default.
- W2374840988 title "Expression of VEGF and its receptors Flt-1 and Flk-1 in human melanoma" @default.
- W2374840988 hasPublicationYear "2011" @default.
- W2374840988 type Work @default.
- W2374840988 sameAs 2374840988 @default.
- W2374840988 citedByCount "0" @default.
- W2374840988 crossrefType "journal-article" @default.
- W2374840988 hasAuthorship W2374840988A5049567302 @default.
- W2374840988 hasConcept C126322002 @default.
- W2374840988 hasConcept C142724271 @default.
- W2374840988 hasConcept C143998085 @default.
- W2374840988 hasConcept C16685009 @default.
- W2374840988 hasConcept C167734588 @default.
- W2374840988 hasConcept C170493617 @default.
- W2374840988 hasConcept C204232928 @default.
- W2374840988 hasConcept C2777025900 @default.
- W2374840988 hasConcept C2777658100 @default.
- W2374840988 hasConcept C2778939058 @default.
- W2374840988 hasConcept C502942594 @default.
- W2374840988 hasConcept C63363279 @default.
- W2374840988 hasConcept C65409693 @default.
- W2374840988 hasConcept C71924100 @default.
- W2374840988 hasConcept C86803240 @default.
- W2374840988 hasConceptScore W2374840988C126322002 @default.
- W2374840988 hasConceptScore W2374840988C142724271 @default.
- W2374840988 hasConceptScore W2374840988C143998085 @default.
- W2374840988 hasConceptScore W2374840988C16685009 @default.
- W2374840988 hasConceptScore W2374840988C167734588 @default.
- W2374840988 hasConceptScore W2374840988C170493617 @default.
- W2374840988 hasConceptScore W2374840988C204232928 @default.
- W2374840988 hasConceptScore W2374840988C2777025900 @default.
- W2374840988 hasConceptScore W2374840988C2777658100 @default.
- W2374840988 hasConceptScore W2374840988C2778939058 @default.
- W2374840988 hasConceptScore W2374840988C502942594 @default.
- W2374840988 hasConceptScore W2374840988C63363279 @default.
- W2374840988 hasConceptScore W2374840988C65409693 @default.
- W2374840988 hasConceptScore W2374840988C71924100 @default.
- W2374840988 hasConceptScore W2374840988C86803240 @default.
- W2374840988 hasLocation W23748409881 @default.
- W2374840988 hasOpenAccess W2374840988 @default.
- W2374840988 hasPrimaryLocation W23748409881 @default.
- W2374840988 hasRelatedWork W1964238095 @default.
- W2374840988 hasRelatedWork W1994991296 @default.
- W2374840988 hasRelatedWork W2017366708 @default.
- W2374840988 hasRelatedWork W2050103641 @default.
- W2374840988 hasRelatedWork W2081508876 @default.
- W2374840988 hasRelatedWork W2095317693 @default.
- W2374840988 hasRelatedWork W2314647783 @default.
- W2374840988 hasRelatedWork W2343372465 @default.
- W2374840988 hasRelatedWork W2358395487 @default.
- W2374840988 hasRelatedWork W2361818409 @default.
- W2374840988 hasRelatedWork W2365146441 @default.
- W2374840988 hasRelatedWork W2378156227 @default.
- W2374840988 hasRelatedWork W2384507132 @default.
- W2374840988 hasRelatedWork W2413877289 @default.
- W2374840988 hasRelatedWork W2525384056 @default.
- W2374840988 hasRelatedWork W2598020 @default.
- W2374840988 hasRelatedWork W2964199746 @default.
- W2374840988 hasRelatedWork W3031741481 @default.
- W2374840988 hasRelatedWork W3031776161 @default.
- W2374840988 hasRelatedWork W823451697 @default.
- W2374840988 isParatext "false" @default.
- W2374840988 isRetracted "false" @default.
- W2374840988 magId "2374840988" @default.
- W2374840988 workType "article" @default.