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- W2374849062 abstract "Objective To evaluate the effects of ketamine,an intravenous anesthetic and NMDA receptor antagonist,on paravertebral ganglion (PVG) neurons of toad (Bufo gargarizans Cantor) in vitro.MethodsIntracellular recordings were obtained from the isolated PVG neurons of toad.ResultsIt was observed that perfusion of ketamine (0.3～3.0 mmol/L,15 min,n=20) concentration-dependently and reversibly depolarized the PVG neurons (P0.05),decreased the amplitude and overshoot of action potential (P0.01),but increased the half-width of spike potential (P0.01).Moreover,the threshold for firing of action potential was significantly raised (P0.05),and the current intensity-firing frequency relationship (I-F) curve was shifted rightward by bath of ketamine,in which action potentials recorded from 20 neurons were all nullified by ketamine at 3.0 mmol/L.Conclusion Ketamine may exhibit an inhibitory action on the toad PVG neurons directly by suppression of the neuronal excitability and decrease of the spike amplitude of action potential." @default.
- W2374849062 created "2016-06-24" @default.
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- W2374849062 date "2005-01-01" @default.
- W2374849062 modified "2023-09-23" @default.
- W2374849062 title "Inhibitory effects of ketamine on paravertebral ganglion neurons of toad in vitro" @default.
- W2374849062 hasPublicationYear "2005" @default.
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