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- W2374859017 abstract "Obsjective:To investigate the impact of Guanxinping on the cardiocytes apoptosis and the expression of Bcl-2 and Bax in the cardiac ischemic canine model.Methods:36 canine dogs were assigned into sham procedure group,cardiac ischemic group,xinkeshu group,and small dose of Guanxinping,median dose of Guanxinping and large dose of Guanxinping group.Before the procedure,the groups were pretreated with control blank capsules,blank capsules,xinkeshu,small dose of Guanxinping,median dose of Guanxinping and large dose of Guanxinping,respectively,for ten days.The cardiac ischemic model was created by ligating a coronary artery,while the sham dogs with the same artery isolated but not ligated.After 180 minutes of ligating,the cardiac tissues were collected from the ligated area.The apoptosis index(AI) of the cardiac myocytes was determined and the expression of the Bcl-2 and Bax were measured by immunohistochemistry.Results:Compared with the control group,the AI of the xinkeshu group,small dose Guanxinping group,median dose of Guanxinping group and large dose of Guanxinping group significantly decreased,while the expression of Bcl-2 and Bax increased.(P0.01) Conclusions:Guanxinping may reduce the impact of the ischemia on the myocytes by reducing the apotosis,which was demonstrated by the decreased expression of Bcl-2 and Bax." @default.
- W2374859017 created "2016-06-24" @default.
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- W2374859017 date "2012-01-01" @default.
- W2374859017 modified "2023-09-28" @default.
- W2374859017 title "The Impact of Guanxinping on the Cardiocytes Apoptosis and the Expression of Bcl-2 and Bax in the Acute Cardiac Ischemic Canine Model" @default.
- W2374859017 hasPublicationYear "2012" @default.
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