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- W2374869531 abstract "Objective:Previous studies showed that expression of gap junction protein connexin 32 (Cx32) and vascular endothelial growth factor (VEGF) may play an important role in tumor occurrence and progression. This study was designed to investigate the effect and relationship of Cx32 and VEGF in metastatic renal cell carcinoma (mRCC). Methods:The expression of Cx32 and VEGF were determined in 44 cases of RCC and 10 cases of normal renal tissue by streptavidin peroxidase immunohistochemistry. Results:In the RCC and normal renal tissue, the positive rates of Cx32 were 27.3% and 90%, the positive rates of VEGF were 79.5% and 20%, with progression of tumor course, Cx32 positive rates decreased(P0.05), but the VEGF positive rate significantly increased (P=0.001). the significant association was observed between Cx32 positive rate and VEGF positive rate (r=-0.660 P=0.001).Conclusions:The expression of Cx32 and VEGF may play a role in occurrence, progression and transformation in RCC. Enhancing the expression of Cx32 may contribute to the activity of anti-VEGF drugs in the treatment of mRCC." @default.
- W2374869531 created "2016-06-24" @default.
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- W2374869531 date "2008-01-01" @default.
- W2374869531 modified "2023-09-24" @default.
- W2374869531 title "The expression and clinical significance of Connexin32、VEGF in metastatic renal cell carcinoma" @default.
- W2374869531 hasPublicationYear "2008" @default.
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