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- W2374869613 abstract "Objective To explore the association of genetic polymorphisms of CYP2D6 and UGT1A6 with risks of chronic benzene poisoning(BP).Methods A case-control study was conducted in 152 BP patients and 152 benzene-exposed workers with no poisoning manifestations.Polymerase chain reaction followed by restriction fragment length polymorphism(PCR-RFLP)technology were used to detect the single nucleotide polymorphisms of g.4268 position in the ninth extron of CYP2D6 gene and t.181 position in the first extron of UGT1A6 gene.Results The individuals carrying CYP2D6 g.4268 C/C genotype had a 1.72-fold(95% CI:1.08～2.78,P=0.03)increased risk of BP compared with those carrying G/G and G/C genotypes.In non-smoking population,there was a 1.75-fold(95% CI:1.03～2.94,P=0.04)increased risk of BP for subjects carrying CYP2D6 g.4268 C/C genotype compared with those carrying G/G and G/C genotypes,and in non-drinking population,the individuals carrying CYP2D6 g.4268 C/C genotype had a 1.82-fold(95% CI:1.09～3.03,P=0.02)increased risk compared with those carrying G/G and G/C genotypes.There is no statistical significance in the distribution of genotypes of UGT1A6 t.181(P0.05)between case and control groups.Conclusions It was suggested that the individuals carrying CYP2D6 g.4268 C/C genotype might be more susceptible to BP." @default.
- W2374869613 created "2016-06-24" @default.
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- W2374869613 date "2005-01-01" @default.
- W2374869613 modified "2023-09-25" @default.
- W2374869613 title "Association of Genetic Polymorphism of CYP2D6 and UGT1A6 with Risks of Chronic Benzene Poisoning" @default.
- W2374869613 hasPublicationYear "2005" @default.
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