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- W2374876074 abstract "Objective To investigate the effects of dexamethasone(DEX) alone and in combination with RU486 on hCG-induced testosterone secretion and c-myb expression in isolated rat Leydig cells.The mechanism of dexamethasone was also analyzed.Methods (1)Testosterone secretion of isolated rat Leydig cells was measured by radioimmunoassay.(2)C-Myb protein of isolated rat Leydig cells was detected by immunohistochemistry.Results DEX(10 -8mol/L)inhibited hCG-induced testosterone secretion in isolated rat Leydig cells.And integral optical density(IOD)immustaining of Myb in Leydig cells was also remarkably reduced.These effects could be blocked by RU486(10 -8mol/L),a dexamethasone antagonist.Conclusion The results indicated that DEX can decrease hCG-induced testosterone secretion,which might be through inhibiting c-Myb synthesis of Leydig cells." @default.
- W2374876074 created "2016-06-24" @default.
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- W2374876074 date "2004-01-01" @default.
- W2374876074 modified "2023-09-23" @default.
- W2374876074 title "Experimental Study of Effect of Dexamethasone on Testosterone Secretion in Isolated Rat Leydig Cells" @default.
- W2374876074 hasPublicationYear "2004" @default.
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