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- W2374879905 abstract "Objective: To study the effects of peroxisome proliferators-activated receptor γ (PPARγ) agonists on TGF-β_1-induced fibrotic response in the renal fibroblasts, so as to investigate its effects on preventing tubulointerstitial fibrosis. Methodology:In cultured rat renal fibroblasts cell line (NRK/49F cells) , the effects of PPARγ ligand 15d-PGJ2and its agonists troglitazone and ciglitazone on the level of TGF-β_1-indued α-smooth muscle actin (α-SMA), connective tissue growth factor (CTGF), fibronectin (FN) and collagen type Ⅲ (Col Ⅲ) mRNA expression was observed by reverse transcriptase-polymerase chain reaction (RT-PCR). The effects of PPARγ agonists on the level of FN protein expression induced by TGF-β_1 were observed by Western Blot. Results:In NRK/49F cells, TGF-β_1 enhanced CTGF, FN and Col Ⅲ mRNA expression in a dose- and time-dependent manner. The level of α-SMA, CTGF, FN, Col Ⅲ mRNA and FN protein expression in 15d-PGJ2, troglitazone and ciglitazone-pretreated groups, respectively, were significantly decreased compared with TGF-β_1-stimulated group. Conclusion:PPARγ agonists may inhibit TGF-β_1-induced CTGF expression and extracellular matrix sythesis in the renal fibroblasts." @default.
- W2374879905 created "2016-06-24" @default.
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- W2374879905 date "2006-01-01" @default.
- W2374879905 modified "2023-09-22" @default.
- W2374879905 title "Effects of peroxisome proliferators-activated receptor γ agonists on TGF-β_1-induced extracellular matrix expression in renal fibroblasts" @default.
- W2374879905 hasPublicationYear "2006" @default.
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