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- W2374879923 abstract "Nonalcohdic fatty liver disease(NAFLD) has been increasingly recognized as the most commonly cause of chronic liver disease in the western world and rich regions in China.Recent studies show that imbalance in gut microbiota plays an important role in the pathogenesis of NAFLD.Changes in constitute and function of gut microbiota can affect energy absorption and fat storage,obesity,development insulin resistance,choline deficiency,interference with metabolism of bile,endogenous mechanisms of ethanol metabolism,promotion of inflammatory cytokine and small intestine motility by SIBO.These are associated with NAFLD or occur from simple fatty liver disease related to NASH.Increasing intestinal permeability,promoting the absorption of gut-derived endotoxemia,liver cells or Kupffer cell activation and pro-inflammatory cytokines generation have played central roles in the incidence of NAFLD and NASH.Moreover,NAFLD progressing to a certain stage will affect the balance of gut microbiota,and ultimately both of a vicious circle." @default.
- W2374879923 created "2016-06-24" @default.
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- W2374879923 date "2011-01-01" @default.
- W2374879923 modified "2023-09-26" @default.
- W2374879923 title "Research progress on gut microbial ecology in the pathogenesis of nonalcoholic fatty liver disease" @default.
- W2374879923 hasPublicationYear "2011" @default.
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