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- W2374885536 abstract "Objective:Abstract Objective:To investigate the possible significance of LRP16 during tumor development and progression and during hematopoietic maturation, bioinformatic and experimental method were employed to detect the expression state of LRP16 intumor development and different hematopoietic stages Methods:Using CGAP/SAGEmap database provided by NCBI as experimental material,Virtual Northernprogram as tool,LRP16 expression pattern was compared among multitumor tissues,cell lines and corresponding normal tissues Semi quantified RT PCR was adopted to compare the expression amount among normal blood cells and leukemic cells Results: Analysis of SAGE pattern showed that LRP16 gene was highly expressed in several human tumor cells than in their normal counterparts LRP16 was not detected in cord blood cells The expression amount of LRP16 gene in normal bone marrow and PBSC(peripheral blood stem cells)mobilized by G CSF were significantly lower than in normal peripheral blood,primary leukemic cells and leukemic cell lines( P 0 0001)such as HL60,K562 and U937 Conclusion:These results suggested that LRP16 have different expression level in different blood cells,and demonstrated that LRP16 is related to AL and many kinds of human tumors The expression difference between diagnostic and relapsed AML is valuable to be further investigated" @default.
- W2374885536 created "2016-06-24" @default.
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- W2374885536 date "2002-01-01" @default.
- W2374885536 modified "2023-09-25" @default.
- W2374885536 title "SAGE pattern of LRP16 gene and its expression in normal blood and leukemic cells" @default.
- W2374885536 hasPublicationYear "2002" @default.
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