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- W2374897513 abstract "AIM To prepare captopril sustained release tablets. METHODS With dissolution as the screening guideline, matrix materials (HPMC, XG, EII, EC, OA) and technical routine (direct compression method, wet granulation method, melting granulation method) were selected to design two factor multilevel complete random experiment. After these, the fillers (Starch, Lactose, CaSO 4) were sifted with the same guideline. RESULTS The optimal formulation and technology were as follows: HPMC as the matrix material, Lactose as the filler and direct compression as the technical routine. Besides these, EII was also a rather goodsustained release matrix material. CONCLUSION Three bates of Cap sustained release tablets prepared according to this optimal formulation and technology conform to Higuchi equation and the drug can be sustainedly released over 12 h in vitro ." @default.
- W2374897513 created "2016-06-24" @default.
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- W2374897513 date "2002-01-01" @default.
- W2374897513 modified "2023-09-23" @default.
- W2374897513 title "Optimal formulation and technology of captopril sustained-release tablet" @default.
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