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- W2374901076 abstract "Objective:The expression of CTGF and MMP-2 in granulation tissue in rat wound surface was observed for the exploration of the mechanism of Compound Luodi Shenggen Ointment for ulcer healing in rats.Methods:One hundred and twenty rats with traumatic ulcer were equally randomized into model control group,conventional treatment group(external application of normal saline gauze) and experimental group(external application of normal saline gauze including growth factor,and external usage of Compound Luodi Shenggen Ointment).On day 1,7 and 14 of the experiment and on ulcer-healing day,ten rats of each group were executed respectively for the observation of CTGF and MMP-2 expression by RT-PCR.Results:The ulcer-healing time in experimental group and conventional treatment group was significantly shortened(P 0.05),and the scar was improved.The difference was significant in CTGF expression level on day 1 and 7,and in MMP-2 expression on day 14 between the two groups(P0.05).Conclusion: Compound Luodi Shenggen Ointment is effective and practical on promoting ulcer healing and improving scar quality in rats with traumatic by regulating the expression of CTGF and MMP-2." @default.
- W2374901076 created "2016-06-24" @default.
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- W2374901076 date "2013-01-01" @default.
- W2374901076 modified "2023-09-24" @default.
- W2374901076 title "Expression of CTGF and MMP-2 in Granulation Tissue of Rat Wound Surface Treated by Compound Luodi Shenggen Ointment" @default.
- W2374901076 hasPublicationYear "2013" @default.
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