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- W2374902023 abstract "Objective To explore the effects of immunotherapy on immunological memory inpatients with advanced gastric cancer.Methods Two hundred and fifty-three patients with advanced gastric cancer who underwent radical surgery in our hospital from October 2013 to February 2015 were enrolled in this study,and they were randomly divided into immunotherapy group(n=72) and control group(n=181) according to whether they had undergone immunotherapy,including dendritic cells(DC) and cytotoxic T cell(CTL).Percentage of CD4~+ T_(CM)(CD4~+CD45RO~+CD62L~+),CD8~+T_(CM),(CD8~+CD45RO~+CD62L~+),CD4~+T_(EM)(CD4~+ CD45RO~+CD62L~-)and CD8~+ T_(EM)(CD8~+CD45RO~+CD62L~-)in peripheral blood was evaluated to analyze immune memory characteristics of advanced gastric cancer patients,furthermore,influence of immunotherapy to immune memory was also analyzed.Results T_(CM),accounted for most of the CD4~+T cells(54.52%±12.76%) while T_(EM)in CD8~+T cells accounted for(24.49%±11.39%).Compared with control group,percentage of CD4~+ T_(CM)and CD8~+ T_(CM) inpatients treated with immunotherapy decreased significantly(CD4~+T_(CM):immunotherapy,47.86%±11.77%,control,60.00%±11.05%,P=0.006;CD8~+ T_(CM):immunotherapy,24.26±7.71%,control,31.59±9.29%,P=0.025),however,CD8~+ T_(EM) increased significantly(control,20.00±8.43%,immunotherapy,29.93±12.40%,P=0.013).Conclusion Memory T cells can effectively evaluate the immune status of advanced gastric cancer,and immunotherapy can be effective in restoring immune depletion status of patients with advanced gastric cancer." @default.
- W2374902023 created "2016-06-24" @default.
- W2374902023 creator A5086576779 @default.
- W2374902023 date "2015-01-01" @default.
- W2374902023 modified "2023-09-28" @default.
- W2374902023 title "Effects of postoperative immunocytes therapy for memory T cell subsets in patients with advanced gastric cancer" @default.
- W2374902023 hasPublicationYear "2015" @default.
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