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- W2374910889 abstract "] Objective It is well known that high-risk human papillomavirus(HPV) infection is the major cause of cervical cancer,and HPV infection can induce a variety of tumors and verruca warts in human.We studied the genotypes of HPV and their clinical characteristics in condyloma acuminate(CA) of the anal canal and anus in Nanjing area.Methods From the paraffin tissue samples from the anal canal and anus of 86 CA patients,we obtained and examined 23 types of HPV DNA by means of PCR and gene-chips technique,followed by analysis of the clinical and pathological data.Results In the 86 patients with CA of the anal canal and anus,the total HPV positive rate was 76.74%(66/86),the rate of single-type HPV infection was 56.98%(49/86),the rate of the predominant type of single infection HPV 11 was 30.23%(26/86),and that of HPV6 was 26.74%(23/86).The rate of the mixed type of HPV infection was 19.77%(17/86);the predominant type of the mixed infection HPV 6+11 was(47.06%,8/17),and that of HPV 6+11+X+X was 29.41%(5/17).Conclusion HPV 11,6,6+11,and 6+11+X+X are the four main types of pathogenesis of CA in the anal canal and anus.The gene-chip method is highly sensitive and specific in the detection and typing of HPV." @default.
- W2374910889 created "2016-06-24" @default.
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- W2374910889 date "2011-01-01" @default.
- W2374910889 modified "2023-09-24" @default.
- W2374910889 title "Genotypes of human papillomavirus in condyloma acuminata in the anal canal and anus" @default.
- W2374910889 hasPublicationYear "2011" @default.
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