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- W2374911692 abstract "Objective To explore the effect of qilian soup-granula on expressions of peroxisome proliferators-activated receptor-r(PPAR-r) in diabetic nephropathy(DN) rats. Methods 55 rats were divided into 10 normal rats and 45 DN rats,which subdivided into model control,high dose and low dose of qilian soup-granula,at 10 and 5 g·kg-1·d-1 for four months.Withdraw the whole blood and isolated monocytes(Mos),and measured the protein expression of PPAR-r in both monocytes and kidneys with western-blot. Results The level of PPAR-r/GAPDH(P/G) in monocytes and kidney of normal control group were(0.857 6±0.069 3) and(0.912 6±0.0.066 7),respectively;in model control were(0.621 9±0.095 0) and(0.706 2±0.097 0);in qilian soup-granula high dose group were(0.806 3±0.081 0) and(0.827 7±0.062 0),which were significant different from those in the model control(P0.05).The level of P/G in low does of qilian soup-granula group was(0.7648±0.087)in Mos,which showed significant difference compaired with the model control. Conclusion Qilian soup-granula could protect against DN in rats,the mechanism of which may be related to eliciting express of PPAR-r in nephridial tissue and Mos,and adjusting the systemic inflammatory state on DN-rats." @default.
- W2374911692 created "2016-06-24" @default.
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- W2374911692 date "2010-01-01" @default.
- W2374911692 modified "2023-09-24" @default.
- W2374911692 title "Effect of Qilian Soup-granula on Expressions of PPAR-r in Diabetic Nephropathy Rats" @default.
- W2374911692 hasPublicationYear "2010" @default.
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