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- W2374922017 abstract "Surface Plasmon Resonance(SPR)is a newly developed biosensor technology which can dynamically detect biomolecular interaction in real time Ricin is a kind of ribosome inactivating protein which is exquisitely toxic to eukaryocyte One molecule of ricin in the cytoplasm can kill the cell,so the immunotoxin constructed with ricin can be used in cancer therapy Monoclonal antibodies against ricin can act as the antitoxin to this poison The kinetics of the interaction between ricin and its monoclonal antibodies C5 and D12 were studied via SPR technique and the affinity constants were calculated The K A values for McAb C5 and McAb D12 were 2.49×10 8 mol -1 ·L and 7.9×10 8 mol -1 ·L respectively.The eqitope analysis showed that the two monoclonal antibodies had different epitopes on ricin molecule" @default.
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- W2374922017 date "1999-01-01" @default.
- W2374922017 modified "2023-09-23" @default.
- W2374922017 title "Studies on the kinetics of the interaction between ricin and its monoclonal antibodies" @default.
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