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- W2374924982 abstract "In this paper,a series of novel naphthalimide-leucine conjugates were designed and synthesized.The structures of all the newly synthesized compounds were characterized by IR,1H NMR,13C NMR and HRMS.Their antitumor activities were evaluated against HeLa,A549,P388,HL-60,MCF-7 and A375 cancer cell lines in vitro by MTT and SRB assay,respectively.The preliminary results show that all of these conjugates have excellent antitumor activities with the IC50 values of 10-6~10-5M.It provides a novel class of naphthalimide-based lead compounds with excellent antitumor activities for further optimization." @default.
- W2374924982 created "2016-06-24" @default.
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- W2374924982 date "2009-01-01" @default.
- W2374924982 modified "2023-09-22" @default.
- W2374924982 title "Synthesis and Potential Antitumor Activity of Novel Naphthalimide Derivatives" @default.
- W2374924982 hasPublicationYear "2009" @default.
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