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- W2374927407 abstract "Objective To study the effect of Wnt/β-catenin signaling on the immunological functions of dendritic cells(DC). Methods The expressions of Wnt pathway components in dendritic cells were identified by RT-PCR. Treatment of immature dendritic cells with SB216763 can activate β-catenin signaling. Then the variation of DC phenotype, expression of cytokines and chemokine receptors were analyzed. Results The mRNA of WNT5A ligands and several receptors of Wnt signaling pathway like Frz1, Frz2, Frz3, LRP6 and ROR2 were expressed on DC. The distribution of WNT5A in the whole cytoplasm was also confirmed by immunofluorescence data. Treatment of immature dendritic cells with SB216763 resulted in an accumulation of β-catenin in the cytosol of DC. And it also induced the up-regulation of co-stimulatory molecules. But the expression of inflammatory cytokines and chemokine receptors were unchanged or even decreased. Conclusion There is a widespread of Wnt signaling components in dendritic cells. The activation of β-catenin signaling induces DC maturation in phenotype. But this kind of DC exhibits a functionally tolerogenic feature." @default.
- W2374927407 created "2016-06-24" @default.
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- W2374927407 date "2010-01-01" @default.
- W2374927407 modified "2023-09-26" @default.
- W2374927407 title "Effect of β-catenin signaling on the function of Dendritic cells" @default.
- W2374927407 hasPublicationYear "2010" @default.
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