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- W2374927891 abstract "ObjectiveTo compare response s of adults between praziquantel resistant and susceptible Schi stosoma mansoni to praziquantel in vitro. Methods Mature adults o f various isolates of S. mansoni were incubated at 37℃ in the MEM medium contai ning 3 2×10 -4 , 8×10 -4 and 1 6×10 -3 mol/L praziquantel res pectivel y. The survival status of worms in the culture were observed on the basis of th e body contractility and movement under a stereo microscope at 15, 30, 45, 60 a n d 75 min. ResultsWhen incubated in MEM medium containing praziqu antel at concentrations of 3 2×10 -4 mol/L in 75 min all of female worms fro m both the resistant and susceptible isolates survived while the survival rates were only 11 5-16 0% and 32 7-36 5% of male worms from the susceptible and r esis tant isolates respectively. When incubated in MEM medium containing praziquantel at concentrations of 8×10 -4 mol/L in 15 min 48 3-50 0% and 57 9-63 6 % of m ale and female worms from the resistant isolates survived while only 22 4-25 9 % and 38 5-48 3% of male and female worms from the susceptible isolates survived . Over 75 min 13 3-17 3% of male worms from the resistant isolates still survive d while no male worms from the susceptible isolates survived. When incubated in ME M medium containing praziquantel at concentration of 1 6×10 -3 mol/L in 1 5 m in no worms of both male and female from the susceptible isolates survived while 11 1-19 6% and 27 5-29 4% of male and female worms from the resistant isola tes survived. ConclusionWhen adults were incubated in MEM medium containing praz iquantel at different concentrations in different times the praziquantel resist a nt isolates exhibited generally higher survival rates than those of praziquantel susceptible isolates, the female worms exhibited generally higher survival rat e s compared with male worms. There were significant differences in responses to p raziquantel at the adults of S. mansoni between praziquantel susceptible and resistant isolates." @default.
- W2374927891 created "2016-06-24" @default.
- W2374927891 creator A5056452441 @default.
- W2374927891 date "2003-01-01" @default.
- W2374927891 modified "2023-09-25" @default.
- W2374927891 title "STUDIES ON RESISTANCE OF SCHISTOSOMA TO PRAZIQUANTELIV. RESPONSE OF ADULTS OF PRA ZIQUANTEL-RESISTANT AND -SUS CEPTIBLE SCHISTOSOMA MANSONI TO PRAZIQUANTEL IN VITRO" @default.
- W2374927891 hasPublicationYear "2003" @default.
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