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- W2374932282 abstract "OBJECTIVE:To analyze Epstein-Barr Virus(EBV) infective status and the probability of suffering from NPC in first-degree relatives of sporadic NPC patients,so as to evaluate the relationship of variation of EBV antibodies and the probability of suffering from NPC with heredity and gender factors.METHODS:Serum samples of first-degree relatives of sporadic NPC patients(relatives group) and normal population from the same area(control group) were collected.ELISA was used to detect the serum levels of VCA / IgA and EBNA1 / IgA.The positive rate of antibody,the high probability of suffering from NPC(high-risk rate) and the detection rate of NPC in different population were calculated.RESULTS:No significant difference was found in the positive rates of VCA / IgA and EBNA1 / IgA between relatives group and control group(P0.05).But in male population,the positive rates of EBNA1 / IgA 、 the high-risk rate and the detection rate of NPC in relatives group were higher than those in control group(P0.05).The positive rate of VCA / IgA was unrelated to the gender in each group(P0.05).But in each group,the male had higher positive rate of EBNA1 / IgA and the highrisk rate than the female(P0.05).The detection rate of NPC in the male control group was higher than that in the female control group(P0.05).CONCLUSIONS:In first-degree relatives of sporadic NPC patients,the male have higher positive rate of EBNA1 / IgA and NPC risk than the normal male,while there is no significant difference in the above index between female relatives and the normal female.In first-degree relatives of sporadic NPC patients,the male have higher NPC risk than the female.The male first-degree relatives have higher mobidity rate of NPC than normal population,which illustrates again that heredity plays an important role in tumorigenesis of NPC." @default.
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- W2374932282 date "2011-12-14" @default.
- W2374932282 modified "2023-09-26" @default.
- W2374932282 title "Analysis of EB Virus antibodies levels and probability of suffering from nasopharyngeal carinoma in first-degree relatives of nasopharyngeal carinoma patients" @default.
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