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- W2374943404 abstract "Pantothenate kinase(PanK),which evolved quickly during evolution,plays an important role in metabolic pathways.PanKs may be potential drug targets to inhibit the growth of certain organisms.In this study,PanK candidate genes from several organisms were cloned,and their PanK activities were demonstrated in an E.coli model.The specificity of four PanKs towards six known or possible antimetabolites was also analyzed.The E.coli results were consistent with results from in vivo cell growth inhibitory experiments.The studies lend further support to the notion that PanKs are potential targets for drug development and suggest the possibility of using high throughput screening for compounds that specifically interact with individual PanKs." @default.
- W2374943404 created "2016-06-24" @default.
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- W2374943404 date "2008-01-01" @default.
- W2374943404 modified "2023-09-24" @default.
- W2374943404 title "Cloning and confirmation of several potential pantothenate kinases and their interaction with pantothenate analogues" @default.
- W2374943404 hasPublicationYear "2008" @default.
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