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- W2374949163 abstract "Objective To investigate the different roles of vascular intimal and adventitial injuries in atherosclerosis and the related signal transduction pathways in rabbits.Methods New Zealand rabbits were fed with high cholesterol diet for two weeks and those without high blood lipid were excluded.Adventitial and intimal injury models were created by digesting rabbit carotid arteries with collagenase.The animals were then divided into non-injury control group,intimal injury group,and adventitial group.Immunochemistry was used to evaluate the difference of atherosclerosis induced by vascular intimal and adventitial injuries,and Western blotting was used to explore the protein expression of P38,ERK1/2 and nuclear factor(NF)-κB in vascular tissues.Results One week later the intimal-to-medial area ratio(IMR)in the adventitial injury group was 0.38±0.02,which was significantly higher than that of the intimal injury group(0.17±0.01,P0.05).Eight weeks later,the IMR in the adventitial injury group was 0.64±0.03,which was significantly lower than that of the intimal injury group(0.75±0.05,P0.05);meanwhile,the expression of P38 and NF-κB protein in the two injury groups was significantly higher than that of the non-injury control group(all P0.05).The ERK1 expression was markedly higher in the intimal injury group compared with the non-injury group(P0.05).Conclusion Both of vascular intimal and adventitial injuries can induce atherosclerosis and activate P38 and MAPK-NF-κB pathway,but they have no effect on ERK1/2 expression." @default.
- W2374949163 created "2016-06-24" @default.
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- W2374949163 date "2009-01-01" @default.
- W2374949163 modified "2023-09-26" @default.
- W2374949163 title "Vascular intimal and adventitia injuries in atherogenesis and signal transduction mechanism:a comparative study" @default.
- W2374949163 hasPublicationYear "2009" @default.
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