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- W2374958602 abstract "Aim To investigate the mechanism by which platelet-derived growth factor (PDGF) stimulates vascular smooth muscle cell proliferation. Methods The vascular smooth muscle cells (A10) were passed down to logarithmic phase,then were incubated with PDGF in various doses and time points. The cell proliferation was detected by MTT assay. The protein levels of AKT and FoxO1/3a were measured by western blot. Results PDGF markedly stimulated proliferation of A10 cells in a dose-and time dependent manner. Moreover, PDGF-induced phosphorylation of AKT and FoxO1/3a was time-dependent manner. Finally, PDGF-stimulated phosphorylation of AKT and FoxO1/3a and proliferation of A10 cells were suppressed by PI3K inhibitor. Conclusions PDGF induces proliferation of A01 cells through activation of AKT and inhibition of FoxO1/3a." @default.
- W2374958602 created "2016-06-24" @default.
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- W2374958602 date "2011-01-01" @default.
- W2374958602 modified "2023-09-25" @default.
- W2374958602 title "Platelet-derived growth factor stimulates vascular smooth muscle cell proliferation through AKT-FoxO signaling pathway" @default.
- W2374958602 hasPublicationYear "2011" @default.
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