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- W2374962414 abstract "Objective:To explore the expression and clinical significance of minibrain-related kinase/dual specificity tyrosine-phosphorylation-regulated kinase 1b(Mirk/Dryk1b) in ovarian tissue. Methods:Immunohistochemical staining method was used to detect the expression levels of Mirk/Dyrk1b in 30 cases with epithelial ovarian cancer,20 cases with epithelial ovarian cystadenoma and 10 cases with normal ovarian tissue. Results:The expression level of Dyrk1b in epithelial ovarian cancer was significantly higher than that in epithelial ovarian cystadenoma and normal ovarian tissue(P0.05),but Dyrk1b rarely expressed in normal ovarian tissue.There was a significant correlation between the positive rate of Dyrk1b and degree of histological differentiation(P0.01),but there was no correlation between the positive rate of Dyrk1b and clinical stage and lymph node metastasis of ovarian cancer(P0.05). Conclusion:The expression level of Dyrk1b in epithelial ovarian cancer is high,which indicates that it may participate in the occurrence and development of epithelial ovarian cancer,and it may become to be a tumor marker for clinical early diagnosis and a new target gene for treatment of ovarian cancer." @default.
- W2374962414 created "2016-06-24" @default.
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- W2374962414 date "2011-01-01" @default.
- W2374962414 modified "2023-09-25" @default.
- W2374962414 title "Expression and clinical significance of Mirk/Dyrk1b in epithelial ovarian cancer tissue" @default.
- W2374962414 hasPublicationYear "2011" @default.
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