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- W2374970404 abstract "AIM:To explore the effect of mesenteric lymph reperfusion (MLR) on blood pressure, survival rate and organ injury in superior mesenteric artery occlusion (SMAO) shock rats.METHODS: Male Wistar rats were randomly divided into 4 groups: in sham group, only anesthetized and operation; in MLR group, performed 1 h occlusion of mesenteric lymphatics (ML) followed by 2 h of reperfusion; in SMAO group, performed 1 h occlusion of superior mesenteric artery (SMA) followed by 2 h of reperfusion; in MLR+SMAO group, performed 1 h occlusion of SMA and ML followed by 2 h of reperfusion. Histopathological and function changes of the lung, liver, kidney and myocardium in rats were assessed after 3 h of mean arterial pressure (MAP) was observed continuously in rats. The survival rate of 24 h was recorded.RESULTS: ① The 24 h survival rates of rats in sham, MLR, SMAO group (100%, 83.3%, 66.7%, respectively) were significant higher than those in MLR+SMAO group (0%). ② The changes of MAP in 4 groups were not statistically different before occlusion. The MAP in SMAO group was higher than that in MLR+SMAO and sham groups at multi-time points after clamping. After reperfusion, the change of MAP in MLR and sham groups was not obvious, and the MAP in SMAO group at multi-time points was decreased than that in MLR and sham groups. MAP in MLR+SMAO group was decreased compared with SMAO, MLR, sham group at all time points after reperfusion. ③ The levels of AST, ALT, BUN, Cre, LDH-1 and CK-MB in MLR+SMAO group in serum were higher than those in sham, MLR and SMAO groups, and these indexes in SMAO group were higher than those in sham and MLR groups. The morphologic observation showed that the structures in kidney, lung, liver and myocardium were normal in sham and MLR groups, however, inflammation, hemorrhage, congestion and necrosis were found in MLR+SMAO group, but only mild histopathological injury was found in SMAO group.CONCLUSION: Our data suggest that the MLR aggravates the multiple organs injury in SMAO shock, therefore, intestinal lymph pathway may play an important role in the pathogenesis of SMAO shock." @default.
- W2374970404 created "2016-06-24" @default.
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- W2374970404 date "2008-01-01" @default.
- W2374970404 modified "2023-09-26" @default.
- W2374970404 title "Effect of mesenteric lymph reperfusion on multiple organs injury in superior mesenteric artery occlusion shock rats" @default.
- W2374970404 hasPublicationYear "2008" @default.
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