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- W2374988086 abstract "Objective To study the effects of the experimental motionsickness on the performance of the mice,and the effect of Difenidol on them,and to study its probable mechanisms.Methods Kunming spices mice were taken to establish motinsickness model and the the effect of Difenidol on pica,learning and memory scores of motinsickness mice was observed.Wistar white rats were taken to establish motinsickness model and the the effect of Difenidol on general conditions,pica,blood sugar,glycogen,lactic acid,lactate dehydrogenase and other biochemical index at different areas on motinsickness rats' brain were observed.Results It indicated that motionsickness model had been successfully eatablished.Difenidol could enhance the motionsickness mice' learning scores,ameliorate the pica of motionsickness mice,decrease the nitrous oxide and malondialchehyche contents in mice' hippocampi,and improve the superoxide dismutase in mice' hippocampi.Conclusions Difenidol can decrease the contraction of brain vessel,improve the distribution of blood flow,and increase blood flow which could relieve partial loss of blood supply and hypoxia in hippocampus and decrease the quantity of free radicals.It might also adjust NO,MDA and SOD in brain cell,increase the excitability of brain cell,then keep the excitability of the central nervous system which might resist motion sickness." @default.
- W2374988086 created "2016-06-24" @default.
- W2374988086 creator A5009999849 @default.
- W2374988086 date "2012-01-01" @default.
- W2374988086 modified "2023-09-23" @default.
- W2374988086 title "The effect of Difenidol on learning ability and biochemical index in experimental motionsickness Mice'Brain" @default.
- W2374988086 hasPublicationYear "2012" @default.
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