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- W2374996356 abstract "BACKGROUND OBJECTIVES: Survivin is a newly identified member of the apoptosis family. This study was to investigate the relationship between the survivin gene expression level in human gliomas and the pathological grade, cell proliferative activity and apoptosis of the tumors. METHODS: Glioma specimens were obtained from 50 patients. Apoptotic cells and apoptotic bodies were detected by TUNEL. Immunohistochemi-cal stains were performed to examine the expression of Fas, Bcl-2, Survivin and PCNA. The software package SPSS 10.0 was used for statistical analysis. RESULTS: The percentage of positive survivin expression was 56% in the 50 specimens. The survivin-positive rate was significantly higher in high-grade tumors as compared with the low-grade tumors (73.9% versus 40.7%, P0.05). Survivin expression was correlated with Bcl-2 expres-sion (P0.01). Survivin weighted scores were negatively correlated (P0. 01) with apoptosis index (AI) and were positively correlated (P0. 01) with proliferation index (PI). There were significant positive linear correla-tions between AI and PI (P0.001). The difference in one-year survival rate between survivin-positive and sur- vivin-negative group was statistically significant(50% versus 78. 9%; P0. 05). Pathologi-cal grade, survivin, AI, PI and degree of surgi-cal resection were independently associated with prognosis of the patients with glioma when analyzed using logistic regression ( P 0.01). CONCLUSION: Over-expression of survivin gene may inhibit apoptosis of glioma cells, and promote the excessive cell proliferation, both of which could play an important role in the development and malignant progres-sion of gliomas. Our results suggest the patients with low-grade tumor, negative for survivin, AI0. 94%, PI16. 50% and undergoing total surgical resection would have better prognosis." @default.
- W2374996356 created "2016-06-24" @default.
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- W2374996356 date "2003-01-01" @default.
- W2374996356 modified "2023-09-27" @default.
- W2374996356 title "Relationship between Survivin Gene Expression and Cell Proliferation or Apoptosis in Human Gliomas" @default.
- W2374996356 hasPublicationYear "2003" @default.
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