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- W2375010614 abstract "The recombinant eukaryotic expression plasmids of Toxoplasma gondii MIC3 gene(pcMIC3)and interferon-gamma gene(pcIFN-γ) were used as vaccine to co-immunize the Balb/c mice for three times every two weeks.The other four groups of mice were set up as control including the plasmids of pcMIC3,pcIFN-γ,pcDNA and phosphate-buffered saline(PBS).The specific antibody in sera of the immunized mice was measured by ELISA,proliferation response of spleno-lymphocyte and CTL activities were detected by MTT and LDH release assay respectively,immune protection effect was observed by challenge with tachyzoites of Toxoplasma gondii RH strain.The results showed that levels titer of the specific antibody and the cellular responses induced by plasmid pcMIC3+pcIFN-γ were excelled that induced by the other plasmids and PBS,and the survival rate reached 100% at 45 days post-challenge,indicating the mice immunized with the plasmids pcMIC3+pcIFN-γ could be protected from lethal Toxoplasma gondii RH strain." @default.
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- W2375010614 date "2007-01-01" @default.
- W2375010614 modified "2023-09-26" @default.
- W2375010614 title "Boost Effect of Interferon-gamma on Immunoprotection of Toxoplasma gondii MIC3 DNA Vaccine in Mice" @default.
- W2375010614 hasPublicationYear "2007" @default.
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